F. Iannelli

Unraveling Glioblastoma Heterogeneity: Introducing SP2G Method for Identifying Invasive Sub-Populations

The paper introduces SP2G, a method to identify invasive sub-populations in glioblastoma cells by analyzing their motility on gridded micropatterns and linking it to molecular markers.

SP2G: an imaging and analysis pipeline revealing the inter and intra-patient migratory diversity of glioblastoma

SP2G identifies invasive glioblastoma sub-populations through an in vivo mimicry platform and imaging analysis, revealing intra-patient heterogeneity in cell motility.

Streptococcus pyogenes Φ1207.3 is a temperate bacteriophage carrying the macrolide efflux gene pair mef(A)-msr(D) and capable to lysogenise different Streptococci

This paper demonstrates that the prophage phi1207.3 from Streptococcus pyogenes can produce mature phage particles and lysogenize different Streptococci, but lacks sufficient lytic activity to form plaques.

Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke

This study identifies Gpr126 as a regulator of BBB development and shows its detrimental role in ischemic stroke, with potential therapeutic implications.

PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.

The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.

Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases

The paper develops 3D organoid cultures using decellularized ECM from colorectal peritoneal metastases to model the metastatic niche and assess chemotherapy response.

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

This study shows that aging-related telomere shortening and DNA damage response increase ACE2 expression, making elderly individuals more susceptible to SARS-CoV-2 infection.

Intra-tumor heterogeneity of Diffuse Large B-cell Lymphoma involves the induction of diversified stroma-tumor interfaces

This study investigates how stromal adaptations in the tumor microenvironment contribute to intra-tumor heterogeneity in DLBCL, showing their impact on transcriptional programs and MYC expression.