J. A. Wohlschlegel

The paper shows that non-exported Plasmodium proteins also contain PEXEL motifs that are processed by PMV, but specific residues in the mature N-terminus determine export.

This paper identifies GRA83 as a Toxoplasma gondii effector that modulates host innate immunity, reducing parasite burden by enhancing inflammatory responses.

This study identifies CHIKV glycoproteins E2 and E1 as key factors that enable macrophages to support viral replication and dissemination by counteracting host restriction factors.

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

This study shows that Trichomonas vaginalis strains communicate via cytoneme-like structures and extracellular vesicles, affecting parasite adherence and potentially influencing clinical outcomes.

This study identifies FAP106 as a critical interaction hub for assembling conserved and lineage-specific microtubule inner proteins at the cilium inner junction in Trypanosoma brucei.

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

This paper identifies SIMC1 and SLF2 as novel subunits forming Nse5/6-like complexes that regulate SMC5/6 localization to viral replication centers and DNA damage sites.

This study identifies a novel Toxoplasma gondii protein that localizes to IMC sutures, regulates suture protein targeting, and colocalizes with membrane trafficking machinery.

The paper investigates the role of MICOS in regulating ferrochelatase activity and heme biosynthesis in yeast, showing that MICOS disruption leads to toxic tetrapyrrole accumulation.

The paper identifies that adenovirus E1A's C-terminal region interacts with host proteins to form a complex that degrades AAA+ ATPases, thereby inhibiting IRF3 stabilization and innate immune responses.

This study shows FAM111A protease mutants cause nuclear dysfunction linked to disease and viral restriction.

This study identifies ESCRT machinery and TFG as components of the Wnt signaling pathway using APEX2 proximity labeling and proteomic analysis.

This paper uses APEX2 proximity proteomics to identify flagellum subdomain-specific proteins in Trypanosoma brucei, revealing tip-specific proteins involved in signal transduction.

This study investigates the role of EXP1 in maintaining the structure of the malaria parasite's parasitophorous vacuole using CRISPR/Cpf1 and BioID2, revealing its critical function in vacuole organization.