Author

A. F. Domingues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

C. Pina· 4 shared S. Gupta· 3 shared B. J. Huntly· 2 shared E. Foerner· 2 shared G. Giotopoulos· 2 shared K. Zeka· 2 shared O. W. Cyran· 2 shared R. Kulkarni· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

C. Pina

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Author profile →

4 papers

Recent·Most cited

MAT2A inhibition in AML unveils therapeutic potential of combining DNA demethylating agents with UPR targeting

K. Zeka, A. V. Taylor, R. Samarista, D. Ragusa, C.-W. Suen, O. W. Cyran, A. F. Domingues, E. Meduri, B. J. Huntly, D. Forte, A. Curti, C. Pina

The paper shows that combining DNA demethylating agents with UPR targeting improves AML cell suppression beyond single-agent therapies.

bioRxiv · Jun 5, 2023 · PreprintCancer Biology

Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis

S. Gupta, O. M. Dovey, A. F. Domingues, O. W. Cyran, C. M. Cash, G. Giotopoulos, J. Rak, J. Cooper, M. Gozdecka, R. J. Asby, N. Al-Jabery, V. Hernandez-Hernandez, S. Prabakaran, B. Huntly, G. S. Vassiliou, C. Pina

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

Unique roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis

L. Arede, E. Foerner, S. Wind, R. Kulkarni, A. F. Domingues, S. Kleinwaechter, S. Gupta, E. Scheer, L. Tora, C. Pina

The paper investigates the distinct roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis, showing ATAC's essential role in stem/progenitor cell maintenance and SAGA's role in cell identity.

bioRxiv · May 14, 2020 · PreprintCell Biology

Loss Of Kat2a Enhances Transcriptional Noise And Depletes Acute Myeloid Leukemia Stem-Like Cells

A. F. Domingues, R. Kulkarni, G. Giotopoulos, S. Gupta, S. Tan, E. Foerner, R. Romano Adao, K. Zeka, B. J. Huntly, S. Prabakaran, C. Pina

This study shows that loss of Kat2a increases transcriptional noise and reduces leukemia stem-like cells in AML by disrupting transcriptional homogeneity.

bioRxiv · Oct 18, 2018Cancer Biology