C. Pina

MAT2A inhibition in AML unveils therapeutic potential of combining DNA demethylating agents with UPR targeting

The paper shows that combining DNA demethylating agents with UPR targeting improves AML cell suppression beyond single-agent therapies.

Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

This study creates a t(7;12) AML model in K562 cells that mirrors patient-specific gene expression and features, aiding in understanding disease mechanisms.

Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

Unique roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis

The paper investigates the distinct roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis, showing ATAC's essential role in stem/progenitor cell maintenance and SAGA's role in cell identity.

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

Loss Of Kat2a Enhances Transcriptional Noise And Depletes Acute Myeloid Leukemia Stem-Like Cells

This study shows that loss of Kat2a increases transcriptional noise and reduces leukemia stem-like cells in AML by disrupting transcriptional homogeneity.