Author

O. W. Cyran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. F. Domingues· 2 shared C. Pina· 2 shared A. Curti· 1 shared A. V. Taylor· 1 shared B. Huntly· 1 shared B. J. Huntly· 1 shared C. M. Cash· 1 shared C.-W. Suen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

A. F. Domingues

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2 papers

Recent·Most cited

MAT2A inhibition in AML unveils therapeutic potential of combining DNA demethylating agents with UPR targeting

K. Zeka, A. V. Taylor, R. Samarista, D. Ragusa, C.-W. Suen, O. W. Cyran, A. F. Domingues, E. Meduri, B. J. Huntly, D. Forte, A. Curti, C. Pina

The paper shows that combining DNA demethylating agents with UPR targeting improves AML cell suppression beyond single-agent therapies.

bioRxiv · Jun 5, 2023 · PreprintCancer Biology

Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis

S. Gupta, O. M. Dovey, A. F. Domingues, O. W. Cyran, C. M. Cash, G. Giotopoulos, J. Rak, J. Cooper, M. Gozdecka, R. J. Asby, N. Al-Jabery, V. Hernandez-Hernandez, S. Prabakaran, B. Huntly, G. S. Vassiliou, C. Pina

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology