A. G. Alvarado

This study compares tumor endothelial cells from low-grade and high-grade gliomas, finding they have distinct molecular profiles and functional roles in regulating tumor growth.

This study uses pathway analysis to identify E2F1 as a key driver of glioblastoma proliferation and shows its inhibition sensitizes tumors to radiation.

The paper shows radiation induces vascular-like phenotypes in glioma stem cells, creating a trophic niche that promotes tumor recurrence, and identifies P300 inhibition as a potential therapeutic strategy.

The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.