Author

S. D. Muthukrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. G. Alvarado· 3 shared H. I. Kornblum· 3 shared R. Kawaguchi· 3 shared A. Pham· 2 shared A. Bhaduri· 1 shared A. Deb· 1 shared A. Lai· 1 shared D. A. Nathanson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

A. G. Alvarado

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3 papers

Recent·Most cited

Low- and high-grade glioma endothelial cells differentially regulate tumor growth

S. D. Muthukrishnan, H. Qi, D. Wang, L. Elahi, A. Pham, A. G. Alvarado, T. Li, F. Gao, R. Kawaguchi, A. Lai, H. I. Kornblum

This study compares tumor endothelial cells from low-grade and high-grade gliomas, finding they have distinct molecular profiles and functional roles in regulating tumor growth.

bioRxiv · Jul 7, 2023 · PreprintCancer Biology

Pathway-based approach reveals differential sensitivity of glioblastoma to E2F1 inhibition

A. G. Alvarado, K. Tessema, S. D. Muthukrishnan, M. Sober, R. Kawaguchi, A. Bhaduri, V. Swarup, D. A. Nathanson, S. A. Goldman, H. I. Kornblum

This study uses pathway analysis to identify E2F1 as a key driver of glioblastoma proliferation and shows its inhibition sensitizes tumors to radiation.

bioRxiv · Jun 19, 2021Cancer Biology

Radiation-reprogrammed glioma stem cells generate vascular-like cells to build a trophic niche driving tumor recurrence

S. D. Muthukrishnan, R. Kawaguchi, P. Nair, R. Prasad, Y. Qin, M. Johnson, N. Vanderveer-Harris, A. Pham, Q. Wang, M. C. Condro, A. G. Alvarado, R. Gau, M. G. Castro, P. R. Lowenstein, A. Deb, , H. I. Kornblum

The paper shows radiation induces vascular-like phenotypes in glioma stem cells, creating a trophic niche that promotes tumor recurrence, and identifies P300 inhibition as a potential therapeutic strategy.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology