Radiation-reprogrammed glioma stem cells generate vascular-like cells to build a trophic niche driving tumor recurrence
S. D. Muthukrishnan, R. Kawaguchi, P. Nair, R. Prasad, Y. Qin, M. Johnson, N. Vanderveer-Harris, A. Pham, Q. Wang, M. C. Condro, A. G. Alvarado, R. Gau, M. G. Castro, P. R. Lowenstein, A. Deb, , H. I. Kornblum
The paper shows radiation induces vascular-like phenotypes in glioma stem cells, creating a trophic niche that promotes tumor recurrence, and identifies P300 inhibition as a potential therapeutic strategy.
bioRxiv · Jun 3, 2021 · PreprintCancer Biology