Author

A. G. Beck-Sickinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:cryo-EM· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:imputation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Brenlla-Lopez· 1 shared A. Morton· 1 shared A. S. Czerniak· 1 shared C. K. Ambrosius· 1 shared C. Zhang· 1 shared G. Gavins· 1 shared G. Kleinau· 1 shared H. Biebermann· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Brenlla-Lopez

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3 papers

Recent·Most cited

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

I. Sohail, S.-A. Laurin, G. Kleinau, V. Chunilal, A. Morton, A. Brenlla-Lopez, Z. C. U. Kagiali, J. A. Tello, M.-J. Blouin, A. G. Beck-Sickinger, M. J. Lohse, P. Scheerer, M. Bouvier, P. McCormick, P. Annibale, H. Biebermann

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

bioRxiv · Apr 9, 2024Pharmacology & Toxicology

Structural basis of CMKLR1 signaling induced by chemerin9

C. Zhang, X. Zhang, T. Weiss, M. H. Cheng, S. Chen, C. K. Ambrosius, A. S. Czerniak, K. Li, M. Feng, I. Bahar, A. G. Beck-Sickinger

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

bioRxiv · Jun 9, 2023 · PreprintBiophysics

Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins

G. Gavins, K. Groeger, M. D. Bartoscheck, P. Wolf, A. G. Beck-Sickinger, S. Bultmann, O. Seitz

The paper introduces a method for live-cell imaging of membrane proteins using PNA tags and demonstrates its application in tracking EGFR internalization.

bioRxiv · Sep 9, 2020Biophysics