T. Weiss

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

Viscoelastic Deformability Cytometry: Ultra-high Throughput Platform for Mechanical Phenotyping of Cells in Liquid and Solid Biopsies

This paper introduces a high-throughput microfluidic platform for measuring cell mechanical properties in liquid and solid biopsies, enabling rapid and accurate mechanical phenotyping of cancer cells.

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

This paper develops a CAR T cell therapy that secretes a CD47 blocker to enhance anti-EGFRvIII efficacy against glioblastoma by modulating the tumor microenvironment.

Structural basis of CMKLR1 signaling induced by chemerin9

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

Efficient protein tagging and cis-regulatory element engineering via precise and directional oligonucleotide-based targeted insertion in plants

This study improves targeted insertion in plants using chemically protected dsODNs with 5' 1-nt overhangs, achieving directional and precise insertions for gene tagging and cis-regulatory engineering in Setaria viridis and rice.

BCAT1 inhibition affects CD8+ T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis

This study shows BCAT1 inhibition alters iron homeostasis, affecting CD8+ T cell activation, exhaustion, and tumor immunity, with potential as a cancer therapy.

The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

Combined sensor-based monitoring of mycothiol redox potential and DNA-damage response in Corynebacterium glutamicum

This study combines redox and DNA-damage biosensors in Corynebacterium glutamicum to show a link between oxidative stress and DNA-damage response, with MSH playing a protective role.

Human repair-related Schwann cells adopt functions of antigen-presenting cells in vitro

This study shows human repair-related Schwann cells exhibit antigen-presenting cell features and suppress T-cell activation in vitro.

Drastic differential CRISPR-Cas9 induced mutagenesis influenced by DNA methylation and chromatin features

This study shows that chromatin features and DNA methylation significantly affect CRISPR-Cas9 mutagenesis efficiency and mutation profiles in Arabidopsis thaliana.

Limited consequences for loss of RNA-directed DNA methylation in Setaria viridis domains rearranged methyltransferase (DRM) mutants

This study examines the effects of losing RNA-directed DNA methylation in Setaria viridis by analyzing methylation patterns and gene expression in drm1ab mutants, finding limited morphological and transcriptional consequences.

Impedance flow cytometry for viability analysis of Corynebacterium glutamicum

This paper introduces impedance flow cytometry to rapidly assess viability of non-growing Corynebacterium glutamicum cultures producing glutamate.

Visualizing the pH in Escherichia coli colonies via the sensor protein mCherryEA allows high-throughput screening of mutant libraries

The paper uses a genetically encoded pH biosensor to screen E. coli mutant libraries and identifies genes involved in pH homeostasis.

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

This study shows that Schwann cells in neuroblastic tumors and injured nerves share repair-related functions, with EGFL8 promoting neuronal differentiation of tumor cells.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

Lineage and Spatial Mapping of Glioblastoma-associated Immunity

This study maps immune cell states and interactions in glioblastoma, identifying IL-10-driven T cell exhaustion and myeloid-lymphoid interactions contributing to immunosuppression.

The Microbes Found in the Honey of New York City Beehives

This study examines microbes in NYC beehive honey to compare microbial differences between urban and rural areas.

Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing in Setaria viridis

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

Unexplained Repeated Pregnancy Loss is Associated with Altered Perceptual and Brain Responses to Men's Body-Odor

The paper investigates whether unexplained repeated pregnancy loss (RPL) in humans is linked to altered olfactory and brain responses to men's body odor, similar to the Bruce effect in mice.

A Bacterial Surface Layer Protein Exploits Multi-step Crystallization for Rapid Self-assembly

This paper shows a bacterial surface layer protein uses a multi-step pathway with a nucleation domain to rapidly crystallize, enabling efficient 2D self-assembly on cell surfaces.

STAT3-dependent systems-level analysis reveals PDK4 as an independent predictor of biochemical recurrence in prostate cancer

The paper identifies PDK4 as an independent prognostic marker for prostate cancer recurrence using gene co-expression networks and proteomics data.

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.