Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
N. J. Henning, A. G. Manford, J. N. Spradlin, S. M. Brittain, J. M. McKenna, J. A. Tallarico, M. Schirle, M. Rape, D. K. Nomura
The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.
bioRxiv · Apr 15, 2021Biochemistry