Author

S. M. Brittain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. K. Nomura· 5 shared J. A. Tallarico· 5 shared J. M. McKenna· 5 shared M. Schirle· 5 shared J. N. Spradlin· 4 shared C. C. Ward· 3 shared J. R. Thomas· 2 shared L. M. McGregor· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersBiochemistry

D. K. Nomura

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Author profile →

5 papers

Recent·Most cited

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin, C. C. Ward, B. Belcher, S. M. Brittain, M. Hesse, D. Dovala, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

bioRxiv · Apr 30, 2021Biochemistry

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

N. J. Henning, A. G. Manford, J. N. Spradlin, S. M. Brittain, J. M. McKenna, J. A. Tallarico, M. Schirle, M. Rape, D. K. Nomura

The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.

bioRxiv · Apr 15, 2021Biochemistry

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

B. Tong, J. N. Spradlin, L. F. T. Novaes, E. Zhang, X. Hu, M. Moeller, S. M. Brittain, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

bioRxiv · Apr 2, 2020Biochemistry

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

C. C. Ward, J. I. Kleinman, S. M. Brittain, P. S. Lee, C. Y. S. Chung, K. Kim, Y. Petri, J. R. Thomas, J. A. Tallarico, J. M. McKenna, M. Schirle, D. K. Nomura

This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.

bioRxiv · Nov 16, 2018Biochemistry