Author

J. M. McKenna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 10 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 11 Approach:experimental assay· 8 Organism:human· 8 Assay:proteomics· 7 Approach:comparative / phylogenetic analysis· 2 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. K. Nomura· 11 shared M. Schirle· 11 shared J. A. Tallarico· 10 shared D. Dovala· 6 shared J. N. Spradlin· 5 shared S. M. Brittain· 5 shared C. C. Ward· 4 shared L. M. McGregor· 4 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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11 shared papersBiochemistry

D. K. Nomura

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Author profile →

11 papers

Recent·Most cited

Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells

F. A. Gowans, D. Q. Thach, Y. Wang, B. E. A. Poblano, D. Dovala, J. A. Tallarico, J. M. McKenna, M. Schirle, T. J. Maimone, D. K. Nomura

This study identifies Ophiobolin A's covalent targets in complex IV of mitochondria, revealing a mechanism of metabolic collapse and cell death in cancer cells.

bioRxiv · Mar 9, 2023Biochemistry

Targeted Protein Degradation through E2 Recruitment

N. Forte, D. Dovala, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This study identifies a covalent recruiter for the E2 ubiquitin conjugating enzyme UBE2D, enabling targeted protein degradation via PROTACs.

bioRxiv · Dec 19, 2022 · PreprintBiochemistry

Rational Chemical Design of Molecular Glue Degraders

E. S. Toriki, J. W. Papatzimas, K. Nishikawa, D. Dovala, L. M. McGregor, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper develops a strategy to convert protein-targeting ligands into molecular glue degraders by identifying a covalent handle that induces proteasome-mediated degradation of target proteins.

bioRxiv · Nov 4, 2022Biochemistry

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB

E. A. King, Y. Cho, D. Dovala, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This study identifies a covalent molecular glue degrader, EN450, that induces the degradation of NFKB1 via a ternary complex with UBE2D, leading to anti-proliferative effects in leukemia cells.

bioRxiv · May 18, 2022Biochemistry

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin, C. C. Ward, B. Belcher, S. M. Brittain, M. Hesse, D. Dovala, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

bioRxiv · Apr 30, 2021Biochemistry

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

N. J. Henning, A. G. Manford, J. N. Spradlin, S. M. Brittain, J. M. McKenna, J. A. Tallarico, M. Schirle, M. Rape, D. K. Nomura

The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.

bioRxiv · Apr 15, 2021Biochemistry

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

B. Tong, J. N. Spradlin, L. F. T. Novaes, E. Zhang, X. Hu, M. Moeller, S. M. Brittain, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

bioRxiv · Apr 2, 2020Biochemistry

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

Y. Isobe, M. Okumura, R. White, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

bioRxiv · Oct 22, 2019 · PreprintBiochemistry

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

C. C. Ward, J. I. Kleinman, S. M. Brittain, P. S. Lee, C. Y. S. Chung, K. Kim, Y. Petri, J. R. Thomas, J. A. Tallarico, J. M. McKenna, M. Schirle, D. K. Nomura

This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.

bioRxiv · Nov 16, 2018Biochemistry