Author

N. J. Henning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. K. Nomura· 3 shared J. M. McKenna· 3 shared J. N. Spradlin· 3 shared M. Schirle· 3 shared C. C. Ward· 2 shared D. Dovala· 2 shared J. A. Tallarico· 2 shared L. Boike· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiochemistry

D. K. Nomura

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin, C. C. Ward, B. Belcher, S. M. Brittain, M. Hesse, D. Dovala, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

bioRxiv · Apr 30, 2021Biochemistry

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

N. J. Henning, A. G. Manford, J. N. Spradlin, S. M. Brittain, J. M. McKenna, J. A. Tallarico, M. Schirle, M. Rape, D. K. Nomura

The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.

bioRxiv · Apr 15, 2021Biochemistry