IL-17A-mediated alterations in gut microbiota composition particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity
S. K. Shahi, S. Ghimire, S. N. Jensen, P. Lehman, A. G. Rux, T.-A. Turner, N. Borcherding, K. Gibson-Corley, S. M. Ganesan, N. J. Karandikar, A. K. Mangalam
This study shows that IL-17A deficiency in mice leads to increased Tregs and beneficial gut microbes like Prevotella, reducing MS-like disease severity.
bioRxiv · Apr 22, 2022 · PreprintImmunology