Author

S. M. Ganesan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:plant (other)· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. C. Niles· 4 shared A. B. Vaidya· 2 shared E. Yeh· 2 shared A. Falla· 1 shared A. G. Rux· 1 shared A. K. Mangalam· 1 shared A. Nilsen· 1 shared A. S. Nasamu· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

J. C. Niles

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

IL-17A-mediated alterations in gut microbiota composition particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

S. K. Shahi, S. Ghimire, S. N. Jensen, P. Lehman, A. G. Rux, T.-A. Turner, N. Borcherding, K. Gibson-Corley, S. M. Ganesan, N. J. Karandikar, A. K. Mangalam

This study shows that IL-17A deficiency in mice leads to increased Tregs and beneficial gut microbes like Prevotella, reducing MS-like disease severity.

bioRxiv · Apr 22, 2022 · PreprintImmunology

An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum

A. S. Nasamu, A. Falla, C. F. A. Pasaje, B. A. Wall, J. C. Wagner, S. M. Ganesan, S. J. Goldfless, J. C. Niles

This paper develops a DNA assembly framework to overcome challenges in genome engineering for Plasmodium falciparum by using linear plasmids for high AT-content DNA constructs.

bioRxiv · Oct 24, 2019Microbiology

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

H. Ke, S. M. Ganesan, S. Dass, J. M. Morrisey, S. Pou, A. Nilsen, M. K. Riscoe, M. W. Mather, A. B. Vaidya

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.

bioRxiv · Oct 5, 2018Microbiology

Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

E. S. Istvan, S. Das, S. Bhatnagar, J. R. Beck, E. Owen, M. LLinas, S. M. Ganesan, J. C. Niles, E. A. Winzeler, A. B. Vaidya, D. E. Goldberg

This study identifies PfNCR1 as a critical protein for Plasmodium falciparum membrane homeostasis and shows it is a potential druggable target for antimalarial drugs.

bioRxiv · Jul 26, 2018Microbiology

Atg8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites

M. Walczak, S. M. Ganesan, J. C. Niles, E. Yeh

This study shows that Atg8 is essential for apicoplast biogenesis in malaria parasites, specifically for its segregation during replication, independent of autophagy.

bioRxiv · Oct 2, 2017Cell Biology

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

K. Amberg-Johnson, S. B. Hari, S. M. Ganesan, H. A. Lorenzi, R. T. Sauer, J. C. Niles, E. Yeh

The paper identifies FtsH1 as a novel druggable target for antimalarial drugs by showing that its inhibition disrupts apicoplast biogenesis in Plasmodium falciparum and Toxoplasma gondii.

bioRxiv · Aug 19, 2017Microbiology