Author

A. K. Mangalam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

S. K. Shahi· 2 shared S. N. Jensen· 2 shared A. G. Rux· 1 shared A. M. Cameron· 1 shared A. Sugiura· 1 shared D. L. Greenwood· 1 shared D. R. Heintzman· 1 shared G. Andrejeva· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

S. K. Shahi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

IL-17A-mediated alterations in gut microbiota composition particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

S. K. Shahi, S. Ghimire, S. N. Jensen, P. Lehman, A. G. Rux, T.-A. Turner, N. Borcherding, K. Gibson-Corley, S. M. Ganesan, N. J. Karandikar, A. K. Mangalam

This study shows that IL-17A deficiency in mice leads to increased Tregs and beneficial gut microbes like Prevotella, reducing MS-like disease severity.

bioRxiv · Apr 22, 2022 · PreprintImmunology

Autoimmunity increases susceptibility to and mortality from sepsis

I. J. Jensen, S. N. Jensen, P. W. McGonagill, T. S. Griffith, A. K. Mangalam, V. P. Badovinac

The paper shows that autoimmune disease increases sepsis susceptibility and mortality using mouse models and clinical data.

bioRxiv · Jul 6, 2021Immunology

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

A. Sugiura, G. Andrejeva, K. Voss, D. R. Heintzman, K. L. Beier, M. M. Wolf, D. L. Greenwood, X. Ye, S. K. Shahi, S. N. Freedman, A. M. Cameron, P. Foerch, T. Bourne, X. Xu, J. C. Garcia-Canaveras, , J. Rathmell

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.

bioRxiv · Feb 3, 2021Immunology