Sensitizing Staphylococcus aureus to antibacterial host defense by decoding and blocking the lipid flippase MprF
C. J. Slavetinsky, J. N. Hauser, C. Gekeler, J. Slavetinsky, A. Geyer, A. Kraus, D. Heilingbrunner, S. Wagner, M. Tesar, B. Krismer, S. Kuhn, C. M. Ernst, A. Peschel
This study develops MprF-targeting monoclonal antibodies that block the lipid flippase MprF, increasing MRSA susceptibility to antimicrobial peptides and antibiotics.
bioRxiv · Nov 12, 2020Microbiology