A. Peschel

Probiotic Lactobacilli activate Formyl-Peptide Receptor 2

This study identifies peptides from probiotic lactobacilli that activate FPR2, promoting immune responses and potentially treating inflammatory gut diseases.

Systematic classification of phage receptor-binding proteins predicts surface glycopolymer structure in Staphylococcus pathogens

The paper develops a computational pipeline to classify phage receptor-binding proteins and predicts surface glycopolymer structure in Staphylococcus pathogens.

Siderophore piracy enables the nasal commensal Staphylococcus lugdunensis to antagonize the pathogen Staphylococcus aureus

This study shows that Staphylococcus lugdunensis reduces S. aureus colonization by producing lugdunin, and that mutualistic interactions with other commensals enhance its growth through siderophore piracy.

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

This study identifies a WTA glycosyltransferase in S. epidermidis that modifies WTA with glucose, altering phage susceptibility and enabling horizontal gene transfer among CoNS species.

The capsular polysaccharide obstructs wall teichoic acid functions in Staphylococcus aureus

The paper investigates how capsular polysaccharide (CP) in Staphylococcus aureus affects wall teichoic acid (WTA) functions, finding that CP interferes with WTA-mediated processes like phage binding and adhesion but enhances virulence.

Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus

This study identifies Lip2 as a Staphylococcus aureus lipase that detoxifies antimicrobial fatty acids via esterification with cholesterol, revealing its role in skin colonization resistance.

Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus

The paper shows that quorum sensing in Staphylococcus aureus controls phage susceptibility by modulating receptor structures, and that cross-species communication with non-aureus staphylococci can protect S. aureus from phage infection.

Targeting of the human nasal microbiota by secretory IgA antibodies

This study identifies bacterial genera and species targeted by sIgA in the nasal microbiome using IgA-seq and sIgA deposition experiments, showing individual variation and epitope-independent interactions with S. aureus.

Horizontal transfer of bacteriocin biosynthesis genes requires metabolic adaptation to improve compound production and cellular fitness

This study shows that transferring bacteriocin biosynthesis genes between Staphylococcus aureus strains requires metabolic adaptation to enhance compound production and cellular fitness.

PplT domain proteins - ubiquitous potential prokaryotic phospholipid translocases

The paper identifies PplT domain proteins in bacteria and archaea as potential phospholipid translocases, showing their role in membrane lipid metabolism and growth.

Sensitizing Staphylococcus aureus to antibacterial host defense by decoding and blocking the lipid flippase MprF

This study develops MprF-targeting monoclonal antibodies that block the lipid flippase MprF, increasing MRSA susceptibility to antimicrobial peptides and antibiotics.

The impact of Staphylococcus aureus cell wall glycosylation on langerin recognition and Langerhans cell activation

This study investigates how different glycosylation patterns on Staphylococcus aureus cell walls affect langerin recognition and Langerhans cell activation, finding that β-GlcNAc is sufficient for langerin binding regardless of its position on WTA.

Phosphoglycerol-type wall- and lipoteichoic acids are enantiomeric polymers differentially cleaved by the stereospecific glycerophosphodiesterase GlpQ

This study demonstrates that WTA and LTA are enantiomeric polymers differentially cleaved by GlpQ, revealing stereochemical differences in their glycerol phosphate moieties.

Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells

This study shows that S. aureus wall teichoic acid is recognized by langerin on human Langerhans cells, driving Th1/Th17 responses and inflammation in skin diseases.