A. Guichet

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes

The paper investigates γ-tubulin complex recruitment mechanisms at mitotic centrosomes in Drosophila, showing that Spd-2 and Cnn use different pathways to nucleate microtubules, with implications for centrosome robustness and microtubule dynamics.

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects

The paper identifies an auto-inhibition domain in Cnn that regulates binding to γ-TuRCs, preventing ectopic microtubule nucleation and cell division defects.

Microtubules originate asymmetrically at the somatic Golgi and areguided via Kinesin-2 to maintain polarity within neurons

The paper shows that microtubules originate asymmetrically at the Golgi in Drosophila neurons and are guided by Kinesin-2 to maintain axonal polarity while excluding dendrites.

Mechanisms of Kinesin-1 activation by Ensconsin/MAP7 in vivo

This study identifies the Kinesin-1 activation mechanism by Ensconsin/MAP7, showing that the KBD domain binds and stimulates Kinesin-1 binding to Mts, with full-length Ensconsin enabling direct activation on microtubules.