P. T. Conduit

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes

The paper investigates γ-tubulin complex recruitment mechanisms at mitotic centrosomes in Drosophila, showing that Spd-2 and Cnn use different pathways to nucleate microtubules, with implications for centrosome robustness and microtubule dynamics.

Daughter centrioles assemble preferentially towards the nuclear envelope in Drosophila syncytial embryos

The paper shows daughter centrioles in Drosophila embryos assemble preferentially toward the nuclear envelope, suggesting non-centrosomal cues guide duplication site establishment.

γ-TuRCs are required for asymmetric microtubule nucleation from the somatic Golgi of Drosophila neurons

This study shows that γ-TuRCs are essential for directional microtubule nucleation from the Golgi in Drosophila neurons, supporting a model of asymmetric microtubule growth and guidance.

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects

The paper identifies an auto-inhibition domain in Cnn that regulates binding to γ-TuRCs, preventing ectopic microtubule nucleation and cell division defects.

Microtubules originate asymmetrically at the somatic Golgi and areguided via Kinesin-2 to maintain polarity within neurons

The paper shows that microtubules originate asymmetrically at the Golgi in Drosophila neurons and are guided by Kinesin-2 to maintain axonal polarity while excluding dendrites.

A positive feedback loop drives centrosome maturation in flies

The paper identifies a positive feedback loop involving Spd-2, Polo, and Cnn that drives centrosome maturation in flies by enabling scaffold expansion.