Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
C. G. K. Ziegler, V. N. Miao, A. H. Owings, A. W. Navia, Y. Tang, J. D. Bromley, P. Lotfy, M. Sloan, H. Laird, H. B. Williams, M. George, R. S. Drake, T. Christian, A. Parker, C. B. Sindel, , J. Ordovas-Montanes
This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.
bioRxiv · Feb 20, 2021Immunology