Protective intravenous BCG vaccination induces enhanced immune signaling in the airways
J. M. Peters, E. B. Irvine, J. M. Rosenberg, M. H. Wadsworth, T. K. Hughes, M. Sutton, S. K. Nyquist, J. D. Bromley, R. Mondal, M. Roederer, R. Seder, P. A. Darrah, J. L. Flynn, A. K. Shalek, S. M. Fortune, B. D. Bryson
This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.
bioRxiv · Jul 16, 2023 · PreprintImmunology