Author

T. Christian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Organism:E. coli· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Y.-M. Hou· 4 shared I. Masuda· 3 shared H. Gamper· 2 shared S. Maharjan· 2 shared A. B. Conn· 1 shared A. Buskirk· 1 shared A. H. Owings· 1 shared A. K. Shalek· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

Y.-M. Hou

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nucleolar Essential Protein 1 (Nep1): Elucidation of Enzymatic Catalysis Mechanism by Combined Molecular Dynamics Simulation and Quantum Chemical Calculations

M. Jedrzejewski, B. Belza, I. Lewandowska, M. Sadlej, A. P. Perlinska, R. Augustyniak, T. Christian, Y.-M. Hou, M. Kalek, J. I. Sulkowska

This study elucidates the catalytic mechanism of Nep1 using molecular dynamics and quantum chemical calculations, revealing that water mediates proton transfer rather than a conserved serine residue.

bioRxiv · Mar 21, 2023 · PreprintBiophysics

tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability

I. Masuda, Y. Yamaki, R. Detroja, S. Tagore, H. Moore, S. Maharjan, Y. Nakano, T. Christian, R. Matsubara, T. M. Lowe, M. Frenkel-Morgenstern, Y.-M. Hou

This study shows that m1G37 tRNA modification neutralizes differential proline codon decoding, and its absence requires a minor isoacceptor for E. coli viability.

bioRxiv · May 14, 2022Microbiology

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

I. Masuda, J.-Y. Hwang, T. Christian, S. Maharjan, F. Mohammad, H. Gamper, A. Buskirk, Y.-M. Hou

This study shows that loss of N1-methylation of G37 in tRNA causes ribosome stalling and alters gene expression, resembling the stringent response.

bioRxiv · May 27, 2021Microbiology

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

C. G. K. Ziegler, V. N. Miao, A. H. Owings, A. W. Navia, Y. Tang, J. D. Bromley, P. Lotfy, M. Sloan, H. Laird, H. B. Williams, M. George, R. S. Drake, T. Christian, A. Parker, C. B. Sindel, , J. Ordovas-Montanes

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

bioRxiv · Feb 20, 2021Immunology

Insights into Genome Recoding from the Mechanism of a Classic +1-Frameshifting tRNA

H. Gamper, H. Li, I. Masuda, D. M. Robkis, T. Christian, A. B. Conn, g. Blaha, E. J. Petersson, R. L. Gonzalez, Y.-M. Hou

This study elucidates the mechanism of +1-frameshifting by tRNA SufB2, showing it uses triplet-slippage and ribosome conformational changes to decode quadruplet codons for genome recoding.

bioRxiv · Dec 31, 2020Biochemistry