Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo
J. Y. K. Wong, S. E. Kirberger, R. Qiu, A. I. Ekanayake, P. Kelich, S. Sarkar, E. R. Alvizo-Paez, J. Miao, S. Kalhor-Monfared, J. J. Dwyer, J. M. Nuss, Y.-S. Lin, M. S. Macauley, L. Vukovic, W. C. K. Pomerantz, R. Derda
This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.
bioRxiv · Aug 22, 2022Biochemistry