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15 papers
Recent·Most cited
G. M. Lima, Z. J. Chenarboo, M. Sojitra, S. Sarkar, E. J. Carpenter, C. Y.-L. Yang, E. Schmidt, J. Lai, A. Atrazhev, D. Yazdan, C. Peng, E. A. Volker, R. Ho, G. Monteiro, R. Lai, , R. Derda
This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.
bioRxiv · Dec 13, 2023 · PreprintBiochemistry
M. Sojitra, E. N. Schmidt, G. M. Lima, E. J. Carpenter, K. A. McCord, A. Atrazhev, M. S. Macauley, R. Derda
This paper introduces a method to measure glycan recognition profiles of lectins on live cells using a liquid glycan array (LiGA) platform and next-generation sequencing.
bioRxiv · Oct 4, 2023Biochemistry
R. Garnham, D. Geh, R. Nelson, E. Ramon-Gil, L. Wilson, E. N. Schmidt, L. Walker, B. Adamson, A. Buskin, A. Hepburn, K. Hodgson, H. Kendall, F. M. Frame, N. J. Maitland, K. Coffey, , E. Scott
This study shows ST3Gal1 promotes immune evasion in prostate cancer by synthesizing Siglec ligands, and its activity can be modulated by enzalutamide.
bioRxiv · Apr 3, 2023 · PreprintCancer Biology
J. Y. K. Wong, S. E. Kirberger, R. Qiu, A. I. Ekanayake, P. Kelich, S. Sarkar, E. R. Alvizo-Paez, J. Miao, S. Kalhor-Monfared, J. J. Dwyer, J. M. Nuss, Y.-S. Lin, M. S. Macauley, L. Vukovic, W. C. K. Pomerantz, R. Derda
This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.
bioRxiv · Aug 22, 2022Biochemistry
C.-L. Lin, M. Sojitra, E. J. Carpenter, E. S. Hayhoe, S. Sarkar, E. A. Volker, A. Atrazhev, T. L. Lowary, M. S. Macauley, R. Derda
This paper develops a method to synthesize genetically-encoded multivalent liquid N-glycan arrays and evaluates their interaction with glycan-binding proteins in vitro and in vivo.
bioRxiv · Aug 5, 2022Biochemistry
J. Jung, J. R. Enterina, D. T. Bui, F. Mozaneh, P.-H. Lin, H. Nitin, C.-W. Kuo, E. Rodrigues, A. Bhattacherjee, P. Raeisimakiani, G. C. Daskhan, C. D. St. Laurent, K.-H. Khoo, L. K. Mahal, W. F. Zandberg, , M. S. Macauley
This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.
ACS Chemical Biology · Oct 18, 2021Peer-reviewedImmunology
A. Bhattacherjee, G. Daskhan, A. Bains, A. E. S. Watson, G. Eskandari-Sedighi, C. D. St. Laurent, A. Voronova, M. S. Macauley
This study shows that CD33L liposomes enhance microglia phagocytosis by multivalently engaging CD33, with effects dependent on CD33's glycan-binding and signaling properties.
bioRxiv · May 8, 2021Immunology
J. R. Enterina, S. Sarkar, L. Streith, J. Jung, B. M. Arlian, S. J. Meyer, H. Takematsu, C. Xiao, T. Baldwin, L. Nitschke, M. J. Shlomchick, J. C. Paulson, M. S. Macauley
This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.
bioRxiv · Apr 30, 2021 · PreprintImmunology
L. Nguyen, K. A. McCord, D. T. Bui, K. A. Bouwman, E. N. Kitova, D. Kumawat, G. C. Daskan, I. Tomris, L. Han, P. Chopra, T.-J. Yang, S. D. Williows, T. L. Lowary, L. J. West, S.-T. D. Hsu, , J. S. Klassen
This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.
bioRxiv · Mar 8, 2021Biochemistry
R. O. Formiga, F. C. Amaral, C. F. Souza, D. A. G. B. Mendes, C. W. S. Wanderley, C. B. Lorenzini, A. A. Santos, J. Antonia, L. F. Faria, C. C. Natale, N. M. Paula, P. C. S. Silva, F. R. Fonseca, L. Aires, N. Heck, , F. Spiller
This paper shows neuraminidase inhibitors reduce neutrophil overactivation in sepsis and COVID-19 by inhibiting sialic acid release and ROS production.
bioRxiv · Nov 12, 2020 · PreprintImmunology
E. Rodrigues, J. Jung, H. Park, C. Loo, S. Soukhtehzari, E. N. Kitova, F. Mozaneh, G. Daskhan, V. Aghanya, S. Sarkar, L. Streith, C. St. Laurent, J.-P. Julien, L. C. West, K. C. Williams, , M. S. Macauley
This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.
bioRxiv · Jul 28, 2020Biochemistry
S. Hong, C. Yu, Y. Shi, P. Wang, D. G. Chapla, E. Rodrigues, K. W. Moremen, J. C. Paulson, M. S. Macauley, P. Wu
The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.
bioRxiv · Jul 15, 2020 · PreprintBiochemistry
M. Sojitra, S. Sarkar, J. Maghera, E. Rodrigues, E. J. Carpenter, S. Seth, D. F. Vinals, N. J. Bennett, R. Reddy, A. Khalil, X. Xue, M. Bell, R. B. Zheng, P. Zhang, C. Nycholat, , R. Derda
The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.
bioRxiv · Mar 24, 2020Biochemistry
S. Hong, C. Yu, P. Wang, Y. Shi, B. Cheng, M. CHEN, D. G. Chapla, N. Reigh, Y. Narimatsu, X. Chen, H. Clausen, K. W. Moremen, M. S. Macauley, J. C. Paulson, P. Wu
This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.
bioRxiv · Mar 23, 2020Bioengineering
R. Ballet, C. Brandl, N. Feng, J. Berri, J. Cheng, B. Ocon, A. Alborzian Deh Sheikh, A. Marki, C. L. Abram, C. A. Lowell, T. Tsubata, H. B. Greenberg, M. S. Macauley, K. Ley, L. Nitschke, E. Butcher
This study identifies CD22-dependent SHP-1 regulation of β7 integrin expression, showing its role in intestinal immunity and pathogen clearance.
bioRxiv · Jan 31, 2020 · PreprintImmunology