J. Miao

Xanthomonas euvesicatoria effector XeAvrRxo1 triggers a Rxo1-mediated defense response in Nicotiana benthamiana and its chaperone Xe4429 functions as an antitoxin, an expression repressor, and an enhancer of XeAvrRxo1 secretion

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

Vacuolar H+-ATPase subunit a was identified as the target protein of the oomycete inhibitor fluopicolide

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses

This paper identifies PfGCN5 as a key regulator of stress responses in Plasmodium falciparum, showing its role in artemisinin resistance and sensitivity to various stress conditions.

Single-cell Transcriptomic Analysis of Systemic Autoinflammatory Diseases with Anti-TNFα Therapy

This study uses single-cell RNA sequencing to analyze PBMCs and PMNs in SAIDs patients before and after anti-TNF therapy, revealing interferon responses in disease activity and unexpected cytokine elevation post-treatment.

Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo

This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

This study identifies a unique GCN5 histone acetyltransferase complex in Plasmodium falciparum that regulates erythrocyte invasion and virulence by modulating chromatin states and gene expression.

An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

CRISPR/Cpf1 mediated genome editing enhances Bombyx mori resistance to BmNPV

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

Outer Membrane Vesicles Mediated Horizontal Transfer of an Aerobic Denitrification Gene between Escherichia coli

This study demonstrates that outer membrane vesicles (OMVs) from E. coli can mediate horizontal transfer of the nirS gene, enabling successful expression and nitrite reductase activity in recipient bacteria.

TLR2 signaling pathway combats Streptococcus uberis infection by inducing production of mitochondrial reactive oxygen species

This study shows that TLR2 signaling reduces S. uberis infection severity by promoting mitochondrial reactive oxygen species production in mammary epithelial cells.

Phenological matching drives wheat pest range shift under climate change

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

Homochiral and racemic MicroED structures of a peptide from the ice nucleation protein InaZ

The paper determines homochiral and racemic structures of a peptide from InaZ using MicroED, revealing amyloid-like protofibrils with distinct chiral arrangements.