R. Qiu

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.

VezA/vezatin facilitates proper assembly of the dynactin complex in vivo

This study identifies VezA/vezatin as a factor essential for dynactin complex assembly in Aspergillus nidulans, highlighting its role in connecting Arp1 mini-filament and pointed-end sub-complex.

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

Aspergillus SUMOylation mutants have normal dynein function but exhibit chromatin bridges

This study identifies SUMOylation defects in Aspergillus nidulans leading to chromatin bridges during mitosis without affecting dynein function.

Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo

This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.

Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport

This study identifies kinesin-1 autoinhibition as a novel regulatory factor that facilitates dynein cargo initiation, distinct from LIS1-promoted dynein switching.

Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain

This study shows that dynein activation in Aspergillus nidulans is regulated by the nucleotide states of its AAA3 domain, with ATP hydrolysis and binding affecting LIS1 interaction and cargo binding.

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

This study investigates the structural dynamics of STIM1's auto-inhibition mechanism using smFRET and crosslinking, revealing how CC1 interacts with CAD to regulate SOCE.

Insights into LIS1 function in cargo-adapter-mediated dynein activation in vivo

This study identifies LIS1's role in promoting dynein activation by switching it from an auto-inhibited to active state through cargo-adapter interactions in Aspergillus nidulans.

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope rupture

This study uses live-cell imaging to characterize the step-wise cellular events of NETosis in neutrophils and identifies PAD4's role in chromatin de-condensation and nuclear envelope rupture.

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.