Author

Y.-S. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Evolutionary Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C.-P. Sun· 3 shared C.-C. Liao· 2 shared C.-C. Lin· 2 shared J.-T. Jan· 2 shared M.-H. Tao· 2 shared P.-Y. Wu· 2 shared Y.-C. Chou· 2 shared Y.-C. Wang· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

C.-P. Sun

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The evolution and structure of snake venom phosphodiesterase (svPDE) highlight its importance in venom actions

C.-T. Pan, C.-C. Lin, I.-J. Lin, K.-Y. Chien, Y.-S. Lin, H.-H. Chang, W.-G. Wu

This study investigates the evolution and structure of snake venom phosphodiesterase (svPDE), showing it evolved from the ENPP3 gene and plays a key role in venom function through purinergic signaling and insulin transduction.

bioRxiv · Nov 24, 2022Evolutionary Biology

Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo

J. Y. K. Wong, S. E. Kirberger, R. Qiu, A. I. Ekanayake, P. Kelich, S. Sarkar, E. R. Alvizo-Paez, J. Miao, S. Kalhor-Monfared, J. J. Dwyer, J. M. Nuss, Y.-S. Lin, M. S. Macauley, L. Vukovic, W. C. K. Pomerantz, R. Derda

This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.

bioRxiv · Aug 22, 2022Biochemistry

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

I.-J. Lee, C.-P. Sun, P.-Y. Wu, Y.-H. Lan, I.-H. Wang, W.-C. Liu, S.-C. Tseng, S.-I. Tsung, Y.-C. Chou, M. Kumari, Y.-W. Chang, H.-F. Chen, Y.-S. Lin, T. -Y. Chen, C.-W. Chiu, , M.-H. Tao

This study evaluates Omicron-specific mRNA vaccines and finds they induce strong neutralizing antibodies against Omicron but not other variants, while bivalent vaccines show broader neutralizing activity.

bioRxiv · Jan 31, 2022Microbiology

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

R. Kulkarni, W.-C. Chen, Y. Lee, C.-F. Kao, S.-L. Hu, H.-H. Ma, J.-T. Jan, C.-C. Liao, J.-J. Liang, H.-Y. Ko, C.-P. Sun, Y.-S. Lin, Y.-C. Wang, S.-C. Wei, Y.-L. Lin, , W. Chang

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

bioRxiv · Aug 3, 2021Immunology

Time to recover from daily caffeine intake.

Y.-S. Lin, J. Weibel, H.-P. Landolt, F. Santini, C. Garbazza, J. Kistler, S. S. Rehm, K. Rentsch, S. Borgwardt, C. Cajochen, C. Reichert

This study examines the effects of daily caffeine intake on cerebral responses, finding that paraxanthine levels remain elevated during withdrawal and cerebral responses are not fully restored after 36 hours of abstinence.

bioRxiv · Jul 1, 2021Pharmacology & Toxicology

The Host Cell's Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope

J. Yoon, E. E. Nekongo, J. E. Patrick, A. M. Phillips, A. I. Ponomarenko, S. J. Hendel, V. L. Butty, C. B. Ogbunugafor, Y.-S. Lin, M. D. Shoulders

This study shows that upregulating the host ER proteostasis network via the UPR reduces mutational tolerance of HIV Env, with some regions becoming more tolerant, suggesting host proteostasis influences HIV adaptation.

bioRxiv · Apr 24, 2021Biochemistry

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

C.-E. Lien, Y.-J. Lin, C. Chen, W.-C. Lian, T.-Y. Kuo, J. D. Campbell, P. Traquina, M.-Y. Lin, L. T. C. Liu, Y.-S. Chuang, H.-Y. Ku, C.-C. Liao, Y.-H. Chen, J.-T. Jan, C.-P. Sun, , Y.-L. Lin

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.

bioRxiv · Jan 7, 2021Microbiology

Geographic and subsequent biotic isolations led to a diversity anomaly of Heterotropa (Aristolochiaceae) in insular versus continental regions of the Sino-Japanese Floristic Region

D. Takahashi, Y. Feng, S. Sakaguchi, Y. Isagi, Y.-X. Qiu, P. Li, R.-S. Lu, C.-T. Lu, S.-W. Chung, Y.-S. Lin, Y.-C. Chen, A. J. Nagano, L. Kawaguchi, H. Setoguchi

This study investigates the diversity anomaly of Heterotropa in insular versus continental regions by analyzing phylogenetic relationships and floral trait evolution.

bioRxiv · Apr 25, 2020Plant Biology