Author

A. I. Gilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

E. I. Shakhnovich· 2 shared A. Marshall-Christensen· 1 shared B. V. Adkar· 1 shared J.-M. Choi· 1 shared S. Bhattacharyya· 1 shared W. Zhang· 1 shared

Activity by Year

2016-2018 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

E. I. Shakhnovich

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2 papers

Recent·Most cited

Substrate inhibition imposes fitness penalty at high protein stability

B. V. Adkar, S. Bhattacharyya, A. I. Gilson, W. Zhang, E. I. Shakhnovich

The paper shows that mutations increasing protein stability in E. coli adenylate kinase lead to substrate inhibition by AMP, reducing enzyme activity and fitness.

bioRxiv · Dec 19, 2018Biophysics

The role of evolutionary selection in the dynamics of protein structure evolution

A. I. Gilson, A. Marshall-Christensen, J.-M. Choi, E. I. Shakhnovich

The paper shows that evolutionary selection for folding stability maintains protein structure despite sequence divergence, but allows rare structural innovations over longer timescales.

bioRxiv · Jun 18, 2016Biophysics