Author

A. Ingargiola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 6 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:bacteria (other)· 2 Approach:microscopy & imaging analysis· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:imputation· 1

Frequent Co-Authors

S. Weiss· 6 shared E. Lerner· 4 shared X. Michalet· 4 shared A. Gulinatti· 3 shared I. Rech· 3 shared M. Ghioni· 3 shared M. Segal· 3 shared I. Labanca· 2 shared

Activity by Year

2017-2019 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersBiophysics

S. Weiss

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6 papers

Recent·Most cited

High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins

M. Segal, A. Ingargiola, E. Lerner, S. Chung, J. A. White, A. M. Streets, S. Weiss, X. Michalet

This paper introduces a high-throughput smFRET method using multispot excitation and SPAD arrays to rapidly analyze nucleic acid and protein conformations and interactions.

bioRxiv · Jun 25, 2019Biophysics

Monte-Carlo Diffusion-Enhanced Photon Inference: Distance Distributions And Conformational Dynamics In single-Molecule FRET

A. Ingargiola, S. Weiss, E. Lerner

This paper introduces MC-DEPI, a method to analyze smFRET data by accounting for distance fluctuations and photo-blinking, showing how these factors affect distance estimation and introducing a machine learning approach to decouple them.

bioRxiv · Sep 21, 2018Biophysics

Characterizing highly dynamic conformational states: the transcription bubble in RNAP-promoter open complex as an example

E. Lerner, A. Ingargiola, S. Weiss

This study uses smFRET and hybrid modeling to identify two conformational states of the transcription bubble in bacterial RPo, supporting a role for sub-millisecond dynamics in transcription start site selection.

bioRxiv · Dec 12, 2017Biophysics

Optical crosstalk in SPAD arrays for high-throughput single-molecule fluorescence spectroscopy

A. Ingargiola, M. Segal, A. Gulinatti, I. Rech, I. Labanca, P. Maccagnani, M. Ghioni, S. Weiss, X. Michalet

The paper examines optical crosstalk in SPAD arrays used for high-throughput single-molecule fluorescence spectroscopy and finds it negligible and undetectable in data analysis.

bioRxiv · Nov 17, 2017Biophysics

48-spot single-molecule FRET setup with periodic acceptor excitation

A. Ingargiola, M. Segal, A. Gulinatti, I. Rech, I. Labanca, P. Maccagnani, M. Ghioni, S. Weiss, X. Michalet

This paper introduces a high-throughput smFRET system using 48 excitation spots and SPAD detectors, enabling rapid subpopulation identification and real-time kinetics studies.

bioRxiv · Oct 26, 2017Biophysics

Multispot single-molecule FRET: high-throughput analysis of freely diffusing molecules

A. Ingargiola, E. Lerner, S. Chung, F. Panzeri, A. Gulinatti, I. Rech, M. Ghioni, S. Weiss, X. Michalet

The paper introduces a multispot confocal setup for high-throughput smFRET assays and validates its performance using bacterial RNA transcription kinetics.

bioRxiv · Jan 28, 2017Biophysics