A. M. Streets

Mapping the temporal transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq

This study maps the temporal transcriptional changes during human white and brown adipogenesis using snRNA-seq, revealing key regulatory dynamics and adipogenic features in health and obesity.

Colour Vision in Stomatopod Crustaceans: more questions than answers

This study investigates colour vision in mantis shrimps, finding they can distinguish colours despite having extensive spectral sensitivities and challenging previous assumptions about their colour processing mechanisms.

Mechanical phenotyping of acute promyelocytic leukemia reveals unique biomechanical responses in retinoic acid-resistant populations

This study identifies mechanical differences between ATRA-resistant and -responsive APL cells, linking cell mechanics to resistance mechanisms.

Characterization of transcript enrichment and detection bias in single-nuclei RNA-seq for mapping of distinct human adipocyte lineages

This study compares snRNA-seq and scRNA-seq in adipose tissue, showing snRNA-seq can identify cell types but has transcript enrichment and detection biases that require normalization.

Paper-Thin Multilayer Microfluidic Devices with Integrated Valves

This paper introduces thin-chip microfluidic devices with integrated valves, demonstrating their utility in high-resolution imaging and single-cell applications.

Histologically resolved spatial multi-omics of human oral squamous cell carcinoma

This paper introduces a technique combining label-free histology with spatially resolved multi-omics to map gene expression and copy number alterations in human oral squamous cell carcinoma.

μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cells

The paper introduces μDamID, a microfluidic platform that combines imaging and sequencing to study protein-DNA interactions in single cells, revealing 3D chromatin organization and gene regulation patterns.

High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins

This paper introduces a high-throughput smFRET method using multispot excitation and SPAD arrays to rapidly analyze nucleic acid and protein conformations and interactions.

On-ratio PDMS bonding for multilayer microfluidic device fabrication

The paper demonstrates that on-ratio PDMS bonding is effective for multilayer soft lithography, avoiding the issues of off-ratio bonding.

Controller for microfluidic large-scale integration

The paper introduces KATARA, an open-source Arduino-based controller for microfluidic devices, enabling precise control of 70 solenoid valves without programming expertise.