Author

A. J. Heck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Brandao· 1 shared A. J. Deutsch· 1 shared A. M. Silva· 1 shared A. Miranda· 1 shared A. Peixoto· 1 shared A. Prokesch· 1 shared A. Reinisch· 1 shared B. Rinner· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Brandao

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells

A. Peixoto, D. Ferreira, A. Miranda, M. Relvas-Santos, R. Freitas, T. S. Veth, A. Brandao, E. Ferreira, P. Paulo, M. Cardoso, C. Gaiteiro, S. Cotton, J. Soares, L. Lima, F. Teixeira, , J. A. Ferreira

This study identifies hypoxia and glucose deprivation as drivers of aggressiveness in bladder cancer through metabolic adaptation and altered glycosylation.

bioRxiv · Oct 21, 2023Biochemistry

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

E. S. Fischer, C. W. Yu, J. F. Hevler, S. H. McLaughlin, S. L. Maslen, A. J. Heck, S. M. Freund, D. Barford

This study investigates how Mps1 phosphorylation of Mad1 facilitates the assembly of the mitotic checkpoint complex by promoting interactions between Mad1, Cdc20, and Bub1.

bioRxiv · May 16, 2022Biochemistry

Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

J. Krstic, I. Reinisch, K. Schindlmaier, M. Galhuber, N. Berger, N. Kupper, E. Moyschewitz, M. Auer, H. Michenthaler, C. Noessing, M. R. Depaoli, J. Ramadani-Muja, S. Stryeck, M. Pichler, B. Rinner, , A. Prokesch

This study shows that fasting enhances the effectiveness of sorafenib in hepatocellular carcinoma by reversing drug resistance through p53-dependent metabolic changes.

bioRxiv · Feb 10, 2021Cancer Biology