Author

A. J. Oakley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. Ghodke· 2 shared J. C. Bouwer· 2 shared N. E. Dixon· 2 shared S. H. J. Brown· 2 shared S. Jergic· 2 shared Z.-Q. Xu· 2 shared A. C. Pradhan· 1 shared A. E. Whitten· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBiochemistry

H. Ghodke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli

Z.-Q. Xu, S. Jergic, A. T. Y. Lo, A. C. Pradhan, S. H. J. Brown, J. C. Bouwer, H. Ghodke, P. J. Lewis, G. Tolun, A. J. Oakley, N. E. Dixon

This study presents six high-resolution structures of the E. coli clamp loader complex (CLC) during the clamp loading process, revealing the molecular mechanism of clamp opening and DNA binding.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

Proposed Mechanism for Monomethylarsonate Reductase Activity of Human Omega-class Glutathione Transferase GSTO1

A. J. Oakley

The paper proposes a reaction mechanism for the monomethylarsonate reductase activity of human GSTO1 using molecular dynamics simulations and comparative analysis with animal homologs.

bioRxiv · Nov 7, 2021Biochemistry

Mechanism of transcription modulation by the transcription-repair coupling factor

B. P. Paudel, Z.-Q. Xu, S. Jergic, A. J. Oakley, N. Sharma, S. H. Brown, J. C. Bouwer, P. Lewis, N. E. Dixon, A. M. van Oijen, H. Ghodke

This study investigates how the bacterial TRCF Mfd modulates transcription by converting elongation complexes into catalytically poised states and then irreversibly terminating transcription through ATP hydrolysis.

bioRxiv · Apr 2, 2021Biophysics

Identification of a novel tetrameric structure for human apolipoprotein-D

C. S. Kielkopf, J. K. K. Low, Y.-F. Mok, S. Bhatia, T. Palasovski, A. J. Oakley, A. E. Whitten, B. Garner, S. H. J. Brown

This study identifies a tetrameric structure of human apolipoprotein-D in breast cyst fluid, contrasting with its monomeric or higher-order forms in other biological fluids.

bioRxiv · May 31, 2018Biochemistry