Author

N. E. Dixon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:E. coli· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 4 Organism:bacteria (other)· 2 Assay:DNA methylation· 2 Approach:microscopy & imaging analysis· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

S. Jergic· 7 shared A. M. van Oijen· 6 shared Z.-Q. Xu· 5 shared H. Ghodke· 4 shared J. S. Lewis· 4 shared L. M. Spenkelink· 3 shared A. J. Oakley· 2 shared A. T. Y. Lo· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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7 shared papersBiochemistry

S. Jergic

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli

Z.-Q. Xu, S. Jergic, A. T. Y. Lo, A. C. Pradhan, S. H. J. Brown, J. C. Bouwer, H. Ghodke, P. J. Lewis, G. Tolun, A. J. Oakley, N. E. Dixon

This study presents six high-resolution structures of the E. coli clamp loader complex (CLC) during the clamp loading process, revealing the molecular mechanism of clamp opening and DNA binding.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase

K. S. Whinn, Z.-Q. Xu, S. Jergic, N. Sharma, L. M. Spenkelink, N. E. Dixon, A. M. van Oijen, H. Ghodke

This study visualizes how the Escherichia coli Rep helicase rescues stalled replication forks by removing roadblocks, showing replication restart is the rate-limiting step.

bioRxiv · Dec 4, 2022 · PreprintBiochemistry

The E. coli helicase does not use ATP during replication.

L. M. Spenkelink, R. R. Spinks, S. Jergic, J. S. Lewis, N. E. Dixon, A. M. van Oijen

The paper shows that the E. coli DnaB helicase does not use ATP during DNA replication, with polymerase-driven nucleotide incorporation providing the energy instead.

bioRxiv · Jul 7, 2021 · PreprintBiochemistry

Mechanism of transcription modulation by the transcription-repair coupling factor

B. P. Paudel, Z.-Q. Xu, S. Jergic, A. J. Oakley, N. Sharma, S. H. Brown, J. C. Bouwer, P. Lewis, N. E. Dixon, A. M. van Oijen, H. Ghodke

This study investigates how the bacterial TRCF Mfd modulates transcription by converting elongation complexes into catalytically poised states and then irreversibly terminating transcription through ATP hydrolysis.

bioRxiv · Apr 2, 2021Biophysics

Recycling of single-stranded DNA-binding protein by the bacterial replisome.

L. M. Spenkelink, J. S. Lewis, S. Jergic, Z.-Q. Xu, A. Robinson, N. E. Dixon, A. M. van Oijen

This study visualizes how the E. coli replisome recruits and recycles single-stranded DNA-binding protein using two mechanisms, showing their physiological relevance.

bioRxiv · Dec 4, 2018Biophysics

A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome

E. Monachino, S. Jergic, J. S. Lewis, Z.-Q. Xu, A. T. Y. Lo, V. L. O Shea, J. M. Berger, N. E. Dixon, A. M. van Oijen

This study identifies a primase-induced conformational switch that enhances the stability of the bacterial replisome by strengthening the interaction between the polymerase holoenzyme and the replicative helicase.

bioRxiv · Nov 13, 2018Biochemistry

Nuclease dead Cas9 is a programmable roadblock for DNA replication

K. Whinn, G. Kaur, J. S. Lewis, G. Schauer, S. Müller, S. Jergic, H. Maynard, Z. Yan Gan, M. Naganbabu, M. P. Bruchez, M. O'Donnell, N. E. Dixon, A. M. van Oijen, H. Ghodke

The paper uses a modified Cas9 protein to create a programmable roadblock for studying DNA replication fork arrest in vitro and in vivo.

bioRxiv · Oct 29, 2018Biochemistry