Author

B. P. Paudel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:DNA methylation· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. van Oijen· 3 shared A. J. Oakley· 1 shared A. L. Moye· 1 shared A. van Oijen· 1 shared C. Franck· 1 shared C. G. Tomlinson· 1 shared C. Gonzalez· 1 shared C. L. Johnston· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

A. M. van Oijen

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Author profile →

4 papers

Recent·Most cited

Mechanism of transcription modulation by the transcription-repair coupling factor

B. P. Paudel, Z.-Q. Xu, S. Jergic, A. J. Oakley, N. Sharma, S. H. Brown, J. C. Bouwer, P. Lewis, N. E. Dixon, A. M. van Oijen, H. Ghodke

This study investigates how the bacterial TRCF Mfd modulates transcription by converting elongation complexes into catalytically poised states and then irreversibly terminating transcription through ATP hydrolysis.

bioRxiv · Apr 2, 2021Biophysics

An α-cyanostilbene derivative for the enhanced detection and imaging of amyloid fibril aggregates

N. R. Marzano, K. M. Wray, C. L. Johnston, B. P. Paudel, Y. Hong, A. M. van Oijen, H. Ecroyd

This paper introduces ASCP, a fluorescent probe with enhanced sensitivity and specificity for detecting amyloid fibrils and oligomeric intermediates compared to ThT.

bioRxiv · Jun 25, 2020Biochemistry

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

B. P. Paudel, A. L. Moye, H. Abou Assi, R. El-Khoury, S. B. Cohen, M. L. Birrento, S. Samosorn, K. Intharapichai, C. G. Tomlinson, M.-P. Teulade-Fichou, C. Gonzalez, J. L. Beck, M. J. Damha, A. M. van Oijen, T. M. Bryan

This study uses single-molecule techniques to show that telomerase can extend and unfold parallel telomeric G-quadruplexes, revealing it acts as a resolvase.

bioRxiv · Feb 26, 2020Biochemistry

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

Y. Zhong, B. P. Paudel, D. Ryan, J. Low, C. Franck, K. Patel, M. Benward, R. Payne, A. van Oijen, J. Mackay

This study investigates the mechanism of CHD4-mediated nucleosome sliding using single-molecule assays, revealing a decoupling of DNA translocation at entry and exit sides.

bioRxiv · Jun 27, 2019Biochemistry