Type II alveolar cells with constitutive expression of MHCII and limited antigen presentation capacity contribute to improved respiratory viral disease outcomes
S. A. Toulmin, C. Bhadiadra, A. J. Paris, J. H. Lin, J. Katzen, M. C. Basil, E. E. Morrisey, G. S. Worthen, L. C. Eisenlohr
This study shows that Type II alveolar cells constitutively express MHCII but have limited antigen presentation capacity, which may help modulate immune responses without excessive inflammation during respiratory viral infections.
bioRxiv · Mar 18, 2021 · PreprintImmunology