Author

G. S. Worthen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

J. S. Brenner· 3 shared A. J. Paris· 2 shared E. E. Morrisey· 2 shared J. Katzen· 2 shared J. Nong· 2 shared J. W. Myerson· 2 shared A. B. Reddy· 1 shared A. Babu· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

J. S. Brenner

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Author profile →

6 papers

Recent·Most cited

Nanoparticle-induced augmentation of neutrophils' phagocytosis of bacteria

K. Rubey, A. R. Mukhitov, J. Nong, J. Wu, V. P. Krymskaya, J. W. Myerson, G. S. Worthen, J. S. Brenner

This study shows that neutrophil-tropic nanoparticles enhance phagocytosis of non-opsonized bacteria by ~50%, suggesting their potential as drug carriers for bacterial infections.

bioRxiv · May 14, 2022 · PreprintImmunology

Circadian regulation of lung repair and regeneration

A. Naik, K. Forrest, Y. Issah, U. Valekunja, A. B. Reddy, E. Hennessy, T. Brooks, A. Babu, M. Morley, G. R. Grant, G. A. FitzGerald, A. Sehgal, G. S. Worthen, D. B. Frank, E. E. Morrisey, S. Sengupta

This study shows that the circadian clock regulates lung repair and regeneration independently of inflammation, identifies the Wnt/β-catenin pathway as a mediator, and links poor circadian rhythms to worse lung infection outcomes.

bioRxiv · Nov 20, 2021Cell Biology

Type II alveolar cells with constitutive expression of MHCII and limited antigen presentation capacity contribute to improved respiratory viral disease outcomes

S. A. Toulmin, C. Bhadiadra, A. J. Paris, J. H. Lin, J. Katzen, M. C. Basil, E. E. Morrisey, G. S. Worthen, L. C. Eisenlohr

This study shows that Type II alveolar cells constitutively express MHCII but have limited antigen presentation capacity, which may help modulate immune responses without excessive inflammation during respiratory viral infections.

bioRxiv · Mar 18, 2021 · PreprintImmunology

Red Blood Cells Function as DNA Sensors

M. Lam, S. Murphy, D. Kokkinaki, A. Venosa, S. Sherrill-Mix, C. Casu, S. Rivella, A. Weiner, J. Park, S. Shin, A. E. Vaughan, B. H. Hahn, A. R. Odom John, N. J. Meyer, C. A. Hunter, , N. S. Mangalmurti

The paper shows red blood cells detect and bind DNA, triggering immune responses during infections.

bioRxiv · Feb 11, 2021 · PreprintImmunology

Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment

J. W. Myerson, P. N. Patel, N. Habibi, L. R. Walsh, Y.-W. Lee, D. C. Luther, L. T. Ferguson, M. H. Zaleski, M. E. Zamora, O. A. Marcos-Contreras, P. M. Glassman, I. Johnston, E. D. Hood, T. Shuvaeva, J. V. Gregory, , J. S. Brenner

This paper identifies nanoparticle supramolecular organization as a predictor of neutrophil uptake in inflamed lungs, demonstrating diagnostic and therapeutic potential for acute lung inflammation.

bioRxiv · Apr 15, 2020 · PreprintBioengineering

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases

A. J. Paris, L. Guo, N. Dai, J. Katzen, P. Patel, G. S. Worthen, J. S. Brenner

This paper introduces a method to create spatially heterogeneous lung injury in mice, enabling better study of drug targeting and regeneration in lung diseases.

PLOS ONE · Apr 3, 2019Peer-reviewedPharmacology & Toxicology