J. S. Brenner

A combination of physicochemical tropism and affinity moiety targeting of lipid nanoparticles enhances organ targeting

This paper combines affinity moiety targeting and physicochemical tropism in lipid nanoparticles to enhance organ targeting, showing improved specificity and uptake in lungs and brain.

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions

This study identifies thrombosis as a risk of lung-targeted cationic lipid nanoparticles and proposes solutions to mitigate clotting without compromising targeting.

Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke

This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.

Nanoparticle-induced augmentation of neutrophils' phagocytosis of bacteria

This study shows that neutrophil-tropic nanoparticles enhance phagocytosis of non-opsonized bacteria by ~50%, suggesting their potential as drug carriers for bacterial infections.

Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

This paper demonstrates a strategy for targeted drug delivery to the injured brain by loading drugs onto pulmonary leukocytes using ICAM-targeting nanocarriers, showing increased brain uptake and therapeutic effect in a mouse model.

Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment

This paper identifies nanoparticle supramolecular organization as a predictor of neutrophil uptake in inflamed lungs, demonstrating diagnostic and therapeutic potential for acute lung inflammation.

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases

This paper introduces a method to create spatially heterogeneous lung injury in mice, enabling better study of drug targeting and regeneration in lung diseases.