Core Protein-Directed Antivirals and Importinβ Can Synergistically Disrupt HBV Capsids
C. Kim, L. F. Barnes, C. J. Schlicksup, A. J. Patterson, B. Bothner, M. F. Jarrold, C.-Y. J. Wang, A. Zlotnick
This study shows that HAP12, a CpAM antiviral, synergizes with importinβ to disrupt HBV capsids, revealing an unexpected mechanism of action involving host protein-induced catalysis.
bioRxiv · Aug 16, 2021 · PreprintMicrobiology