Author

A. J. Yool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. L. Adelson· 3 shared S. Nourmohammadi· 3 shared Y. Harata-Lee· 3 shared Z. Qu· 3 shared H. Shen· 2 shared J. Cui· 2 shared T. N. Aung· 2 shared D. Kortschak· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersPharmacology & Toxicology

D. L. Adelson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

H. Shen, S. Nourmohammadi, Y. Zhou, Y. Harata-Lee, Z. Qu, W. Wang, A. J. Yool, D. L. Adelson

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

bioRxiv · May 3, 2024 · PreprintPharmacology & Toxicology

Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain and breast cancer cell lines

S. Nourmohammadi, T. N. Aung, J. Cui, J. V. Pei, M. L. De Ieso, Y. Harata-Lee, Z. Qu, D. L. Adelson, A. J. Yool

This study evaluates the effects of Compound Kushen Injection and its components on cancer cell migration and invasion in multiple cell lines, finding reduced motility and invasiveness.

bioRxiv · Dec 19, 2018Cancer Biology

Fractional Deletion Of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical For Its Perturbation Of The Cell Cycle.

T. N. Aung, S. Nourmohammadi, Z. Qu, Y. Harata-Lee, J. Cui, H. Shen, A. J. Yool, T. Pukala, H. Du, D. Kortschak, D. L. Adelson

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

bioRxiv · Dec 9, 2018Pharmacology & Toxicology