Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages
D. Ahmed, D. Roy, A. Jaworski, A. Edwards, A. Abizaid, A. Kumar, A. Golshani, E. Cassol
The paper shows that TLR3 and TLR4 signaling in macrophages involves differential remodeling of the electron transport chain, which affects ROS production and cytokine responses.
bioRxiv · Aug 21, 2019Immunology