D. Roy

Towards optical measurements of membrane potential values in Bacillus subtilis using fluorescence lifetime

This paper introduces a fluorescence lifetime-based method to measure membrane potential in Bacillus subtilis, achieving single-cell resolution and quantification of MP changes under chemical perturbations.

BUTYRATE AMELIORATES INFLAMMATION IN COLON BIOPSY SAMPLES OF IBD PATIENTS AND EXPERIMENTAL COLITIS IN MICE INVOLVING RNA BINDING PROTEIN, AUF1-IL-27 AXIS AND ACCELERATING B1a TO B10 POLARIZATION

This paper shows butyrate enhances B10 cell generation via the AUF1-IL-27 axis in IBD patients and mice, reducing inflammation.

ROS responsive Aux/IAA multimerization modulates auxin responses

The paper shows ROS-induced IAA3/SHY2 multimerization regulates auxin responses during xerobranching and lateral root emergence in plants.

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

This study compares bacterial infectivity in droplet nuclei formed from evaporating respiratory fluid on a hydrophilic substrate versus in a contact-free environment.

POLARIS is a copper-binding peptide required for ethylene signalling control in Arabidopsis.

The paper identifies PLS as a copper-binding peptide that modulates ethylene signaling in Arabidopsis by interacting with ETR1 and regulating copper-dependent repression of ethylene responses.

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

Super-resolution imaging of highly curved membrane structures in giant vesicles encapsulating molecular condensates

This study uses super-resolution microscopy to image highly curved membrane structures in synthetic cells, revealing membrane properties and their agreement with theoretical predictions.

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

Metabolism of long-chain fatty acids affects disulfide bond formation in Escherichia coli and activates envelope stress response pathways as a combat strategy

This study shows that long-chain fatty acid metabolism in E. coli affects disulfide bond formation and activates envelope stress response pathways to maintain redox homeostasis.

PSP2, a gene encoding RGG-motif protein, is a novel suppressor of clathrin heavy chain deficiency

This study identifies PSP2 as a novel suppressor of clathrin heavy chain deficiency, showing its RGG-motif is essential for function, while other RGG-motif proteins do not suppress the deficiency.

Purification of native CCL7 and its functional interaction with selected chemokine receptors

This study describes a method to purify native CCL7 and its isotopically labeled derivatives, enabling structural and functional studies of chemokine receptor interactions.

Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages

The paper shows that TLR3 and TLR4 signaling in macrophages involves differential remodeling of the electron transport chain, which affects ROS production and cytokine responses.

Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

Identification and classification of hubs in miRNA target gene networks in human neural stem/progenitor cells following Japanese encephalitis virus infection

The paper identifies and classifies hub genes in miRNA target networks of human neural stem/progenitor cells infected with Japanese encephalitis virus.