Engineered protein-small molecule conjugates empower selective enzyme inhibition
A. K. Lewis, A. Harthorn, S. M. Johnson, R. R. Lobb, B. J. Hackel
The paper introduces a platform to create protein-small molecule hybrids (PriSMs) that enhance enzyme inhibition specificity and potency compared to small molecules or proteins alone.
bioRxiv · May 5, 2021Bioengineering