A. K. Miller

Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles.

The paper investigates how stromal factors indirectly enhance tumor chemoresistance by accelerating tumor recovery between chemotherapy cycles through paracrine signaling.

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs

The paper identifies antioxidant-capacity biomarkers (ACBs) that predict susceptibility to ROS-inducing drugs in lung cancer cells, showing that low ACB expression correlates with nitric oxide levels, not ROS levels.

Confusion will be my epitaph: Genome-scale discordance stifles phylogenetic resolution of Holothuroidea

This study performs the first phylogenomic analysis of sea cucumbers, finding that genome-scale discordance prevents resolving relationships among Neoholothuriida clades.

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease

This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.

RefZ and Noc act synthetically to prevent aberrant divisions during Bacillus subtilis sporulation

This study identifies a synthetic interaction between RefZ and Noc in Bacillus subtilis sporulation, revealing their combined role in preventing aberrant cell divisions.

Slippery when wet: cross-species transmission of divergent coronaviruses in bony and jawless fish and the evolutionary history of the Coronaviridae

The paper identifies divergent coronaviruses in bony and jawless fish, revealing cross-species transmission and distinct evolutionary patterns within the Coronaviridae family.

Genomes of gut bacteria from Nasonia wasps shed light on phylosymbiosis and microbe-assisted hybrid breakdown

The paper analyzes gut bacterial genomes in Nasonia wasps to understand phylosymbiosis and bacterial-assisted hybrid breakdown, finding that hybrid bacteria are identical to parental species.

What is the storage effect, why should it occur in cancers, and how can it inform cancer therapy?

The paper explores the storage effect as a mechanism for intratumor heterogeneity, arguing that it may explain cancer diversity and inform therapy.

Physiological properties and tailored feeds to support aquaculture of marbled crayfish in closed systems

This study evaluates the physiological traits and tailored feeds for marbled crayfish in closed aquaculture systems, finding comparable size to farmed crayfish and a high chitin content with efficient feed conversion.

A DNA-binding protein tunes septum placement during Bacillus subtilis sporulation

This study identifies RefZ as a DNA-binding protein that regulates septum placement during Bacillus subtilis sporulation by interacting with DNA motifs and modulating FtsZ function.