A. Marusyk

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles.

The paper investigates how stromal factors indirectly enhance tumor chemoresistance by accelerating tumor recovery between chemotherapy cycles through paracrine signaling.

Understanding the Evolutionary Games in NSCLC Microenvironment

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

Antifragile therapy

This paper introduces a mathematical framework to quantify cancer cell line fragility or antifragility to treatment variability and applies it to treatment resistance and collateral sensitivity.

Measuring competitive exclusion in non-small cell lung cancer

This study measures frequency-dependent interactions between gefitinib-resistant and sensitive NSCLC populations to show that competitive exclusion depends on growth rate data, not just cost of resistance.

High school Internship Program in Integrated Mathematical Oncology (HIP IMO) - five-year experience at Moffitt Cancer Center

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

Spontaneous Cell Fusions as a Mechanism of Parasexual Recombination in Tumor Cell Populations

This study investigates spontaneous cell fusions in tumor cell populations as a mechanism of parasexual recombination, finding evidence of low-frequency fusions and their role in increasing clonal heterogeneity.

Selection-driven tumor evolution involving non-cell growth promotion leads to patterns of clonal expansion consistent with neutrality interpretation

This study uses agent-based modeling to show that tumor evolution driven by space acquisition and proliferation can produce clonal patterns resembling neutral evolution.

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

The paper identifies collagen production as an adaptation strategy in acidotic cancer cells, showing correlation with patient survival.

Fibroblasts and Alectinib switch the evolutionary games played by non-small cell lung cancer

The paper develops a game assay to measure evolutionary games in cancer cell co-cultures, showing that fibroblasts and Alectinib shift the game type from Leader to Deadlock.

The impact of tumor stromal architecture on therapy response and clinical progression

This paper investigates how tumor stromal architecture influences therapy response and resistance in lung, breast, and kidney cancers using mathematical models, experimental studies, and clinical analysis.

Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs

This paper develops a dynamical model to determine optimal drug switching schedules for collaterally sensitive drugs in cancer treatment, finding that the initial drug phase should be shorter than its effective duration.