J. C. Sacchettini

Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization

This paper characterizes YisK in Bacillus subtilis, showing it has oxaloacetate decarboxylase activity and Mbl-dependent localization.

Structural anatomy of C1 domain interactions with DAG and other agonists

The paper reports high-resolution crystal structures of a C1 domain bound to DAG and agonists, revealing mechanisms of lipid recognition and guiding drug design.

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism

The paper identifies Sfh5 as a novel heme-binding protein with an unusual coordination mechanism, distinct from its Sec14-like PITP family members.

Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

This study identifies Rv3722c as the primary aspartate aminotransferase in Mtb, revealing its role in nitrogen distribution and highlighting it as a potential drug target.

A DNA-binding protein tunes septum placement during Bacillus subtilis sporulation

This study identifies RefZ as a DNA-binding protein that regulates septum placement during Bacillus subtilis sporulation by interacting with DNA motifs and modulating FtsZ function.

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.