Destruction of DNA-binding proteins by programmable O'PROTAC: Oligonucleotide-based PROTAC
J. Shao, Y. Yan, D. Ding, D. Wang, Y. He, Y. Pan, W. Yan, A. Kharbanda, H.-y. Li, H. Huang
This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.
bioRxiv · Mar 8, 2021 · PreprintBiochemistry