J. Shao

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

Long noncoding RNA Hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis

This study identifies Hottip as a regulator of skeletal homeostasis by suppressing the Ezh2/histone methylation axis, affecting osteoblast and osteoclast differentiation.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

SIDERITE: Unveiling Hidden Siderophore Diversity in the Chemical Space Through Digital Exploration

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

CD3+ T-cell: CD14+monocyte complexes are dynamic and increased with HIV and glucose intolerance

The paper identifies increased CD3+ T-cell:CD14+ monocyte complexes in diabetes and HIV, associated with inflammation and metabolic changes.

Siderophore-mediated iron partition promotes dynamical coexistence between cooperators and cheaters

The paper shows that siderophore-mediated iron partition enables stable coexistence between cheaters and partial cooperators in microbial communities.

ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

This study shows that OPA1 deficiency in skeletal muscle increases MERC formation via ATF4, affecting calcium exchange and mitochondrial-ER tethering.

BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesity

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

This study investigates how DRP1 mutations affect mitochondrial and peroxisomal dynamics, leading to metabolic dysfunction and structural abnormalities in EMPF1 patient fibroblasts.

U2AF1 is a haplo-essential gene required for cancer cell survival

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Annulment of antagonism shifts properties that are beneficial to plants in two-member consortia of Bacillus velezensis

This study shows that modifying the Spo0A gene in B. velezensis SQR9 improves plant growth promotion when combined with FZB42 in two-member consortia.

A unique genomic island-governed cannibalism in Bacillus enhanced biofilm formation through a novel regulation mechanism

This study identifies a novel cannibalism mechanism in Bacillus velezensis SQR9 mediated by bacillunoic acids, enhancing biofilm formation and interspecies competition through a two-component regulatory system.

Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery

This paper describes methods to identify and distinguish subcellular structures involved in macroautophagy using TEM and 3D reconstruction, with applications to quantify degradation machinery under different conditions.

Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

Effect of ORF7 of SARS-CoV-2 on the chemotaxis of monocytes and neutrophils in vitro

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

Kinetic tracking of Plasmodium falciparum antigen presentation reveals determinants of protein export and membrane insertion

The paper introduces RISE, a method to track antigen exposure in malaria parasites, revealing factors influencing protein export and membrane insertion.

A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

The volatile cedrene from plant beneficial Trichoderma guizhouense modulates Arabidopsis root development through auxin transport and signaling

Destruction of DNA-binding proteins by programmable O'PROTAC: Oligonucleotide-based PROTAC

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

A multiepitope fusion protein-based p-ELISA method for diagnosing bovine and goat brucellosis

This paper develops a p-ELISA method using a multiepitope fusion protein to diagnose bovine and goat brucellosis, achieving high sensitivity and specificity.

Monomethyl branched-chain fatty acid mediates amino acid sensing by mTORC1

This study identifies a leucine-derived fatty acid and glycosphingolipid that mediate amino acid sensing by mTORC1 in C. elegans, regulating development through protein translation and ribosomal biogenesis.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway

This study shows decorin reduces high glucose-induced apoptosis and oxidative stress in lens epithelial cells by inhibiting the p22phox-p38 MAPK pathway.