13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation
A. Kirchmair, N. Nemati, G. Lamberti, M. P. Trefny, A. Krogsdam, A. Siller, P. Hörtnagl, P. Schumacher, S. Sopper, A. M. Sandbichler, A. Zippelius, B. Ghesquiere, Z. Trajanoski
This study uses 13C metabolomics and transcriptomics to analyze metabolic changes in CD8+ T cells during differentiation, identifying key metabolic checkpoints and their role in exhaustion.
bioRxiv · May 18, 2023 · PreprintImmunology